Recently I found that when my Safari started up, it would fail to load my homepage, http://home.netscape.com/apple.adp. Every time I tried to access this page, it would try to redirect to http://startpage.apple.com, which would redirect it to http://home.netscape.com/apple.adp, and it would go into a loop. I found an article at Macosxhints.com that described how to fix this.
Check out http://forums.macosxhints.com/showthread.php?s=&threadid=33429 to see the original article.
Essentially, what you need to do is to go into your Safari Preferences, into the Security section, click the Show Cookies button, then delete any cookies in the list that have come from Netscape.